Albert Science International Organization

ARTICLE DESCRIPTION: 

Shubham Verma, Dharmendra Kumar Shrivastava, Yogendra Singh, Vishnu Kant Rai, Phytochemical investigations of dismondium gengeticum plant extract and its study for anti-inflammatory activity, ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR), 2025, 9(1): 16-24.

1-3Shri Ramnath Singh Mahavidyalaya (Pharmacy), Gormi, Bhind (M.P.) – 477660, India

4Azad College of Education (Pharmacy), Sakha Janwara, Ghatampur, Kanpur Nagar, U.P., India

ARTICLE TYPE: REVIEW

DOI : 10.2016-19146535/ ; DOI Link :: Digital Link :: https://doi-ds.org/doilink/09.2025-83376899/ASIO-JPHMR/V9/I1/SV

ABSTRACT

In many different parts of the world, D. gangeticum has long been utilized as a medicine. Shalaparni root decoction is used as a snake bite treatment in India. The goal of this study was to determine the pharmacological properties of the Dismondium gengeticum leaf extract. Petroleum ether (PE) and 50% v/v ethyl alcohol were used to extract the dry and powdered leaf parts. The purpose of this study was to assess the phytochemical and pharmacological significance of the extract from Dismondium gengeticum leaves and investigate their anti-inflammatory properties. Formalin-induced rat paw edema was used to assess the anti-inflammatory properties of the standard and various test groups that included 50% ethanolic extract of Dismondium Gengeticum leaves. The evaluation's findings were observed using diclofenac sodium as the reference medication. A gradual edema was caused by the injection of formalin into the hind paw, which peaked five hours later. The paw thickness of the animals in Group I was 0.75 ±0.04 mm at t = 0. The animals in Group I had paws that were 1.78 ±0.04 mm thicker after 0.5 hours, 2.82 ±0.16 mm thicker after 1 hour, 3.86 ±0.28 mm thick after 2 hours, 4.95 ±0.38 mm thick after 3 hours, 5.02 ±0.22 mm thick after 4 hours, and 5.04 ±0.24 mm thick after 5 hours. Furthermore, test group IV, which contained 400 mg/kg body weight of a 50% ethanolic extract of Dismondium Gengeticum leaves, had comparatively higher activity than test group III. In the same way group III, test groups containing (200 mg/kg body weight) 50 % ethanolic extract of leaves of Dismondium Gengeticum compounds of this series showed insignificant anti-inflammatory activity except standard group and test group IV. Therefore, it can be recommended that future human research examine the harmonizing effect of combining diclofenac sodium with an ethanolic extract of Dismondium Gengeticum leaves on different bodily tissues.

Keywords: Dismondium Gengeticum, leaves, ethanolic extract, anti-inflammatory activity, Shalaparni.

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