Albert Science International Organization

ARTICLE DESCRIPTION: 

Jugal Kishor, Ashok Singh Baghel, Yogendra Singh, V K Rai, Preparation & evaluation of microemulsion based gel of luliconazole, ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR), 2025, 9(1): 01-15.

^1-3Shri Ramnath Singh Mahavidyalaya (Pharmacy), Gormi, Bhind (M.P.) – 477660, India

⁴Azad College of Education (Pharmacy), Sakha Janwara, Ghatampur, Kanpur Nagar, U.P., India

ARTICLE TYPE: REVIEW

DOI : 10.2016-19146535/ ; DOI Link :: https://doi-ds.org/doilink/08.2025-29567395/ASIO-JPHMR/V9/I1/JK

ABSTRACT

Fungal infection is generally characterized by progressive onsets of species of fungi and causes severe health problems in immune-restricted individuals with high morbidity and mortality. Solid lipid nanoparticles (SLNs) have become an innovative, modern-day pharmaceutical novel drug delivery device (NDDS). Luliconazole has poor water solubility (0.0659 mg/ml) which makes its penetration limited to lipid bilayer of skin. In latest years nano-carriers form topical formulation such as nanoparticles, nanoemulsions, nanocrystals, solid lipid nanoparticles etc. have obtained most importance as likely drug carrier for topical delivery due to their each advantages and great potential as differentiate to normal formulations like higher drug payload capacity, higher permeability, high solubility use of low amount of excipients, high chemical stability, low toxicity and manufacturing. In this study, Luliconazole loaded with solid lipid nanoparticles (SLNs) will develop to increase penetration of drug to skin owing to lipidic nature of SLNs and further drug loaded SLNs were absorb inside gel to enhance skin retention time. Hence, present study is associated with optimization and evaluation of topical gel containing SLN loaded with Luliconazole. Further, prepared best SLN formulation is prepared and evaluated for getting a carbopol based topical gel. The particle size analysis of luliconazole SLN suspension revealed that the particle size measured by laser light method is around to 130-245 nm with low polydispersity index. All the SLN formulation shows particle sizes in the nano range (< 1 μm). The reduced particle size and polydispersity index could be attributed to the stabilization of colloidal system. Zeta potential is one of the important parameters used to forecast the physical stability of nanoparticles. The stability of the nanoparticle system depends on the high zeta potential value which points toward better stability of the nanosystem since it could deliver a deterring force between the nanoparticles. SLN shows a zeta potential -22.2 mV with conductivity 17.6mS/cm and states to the high stability of the nanosystem. The in vitro drug diffusion study of the formulated Luliconazole nanoemulgel was conducted for 12 h, during which the formulation showed a release rate of 84.813% to 96.89% . In vitro release investigation of drug-loaded gels demonstrated optimum in vitro drug release up to 12 h. The in vitro release of the drug from the SLN dispersion gel was found to be biphasic, with the initial burst effect followed by steady release of the drug. According to SEM analysis, the Luliconazole containing SLN in the gel had a spherical form and a smooth surface.  By using the solvent diffusion approach Luliconazole loaded solid lipid nanoparticle were successfully created. There was determined to have 94.21±0.045entrapment efficiency. 130.5nm was found to be the particle size and 0.265PDI and zeta potential -22.2 mV of the developed formulation LSLN6. The size of the SLN increased along with the amount of lipid. The compatibility of the medicine and excipients is strongly suggested by ATR-FTIR. The Luliconazole loaded SLN LG3 gel formulation with carbopol 934 (1.5% w/v) are best as an optimal formulation and acceptable for topical use according to the findings of the current study.

Keywords: Luliconazole nanoemulgel, topical use, SLNs, carbopol 934.

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