Albert Science International Organization

ARTICLE DESCRIPTION: 

Lavali Singh, Ashok  Singh Baghel ,  Dinesh Kumar Sharma, Vishnu Kant Rai, Yogendra Singh, Development and evaluation of fast dissolving tablets of Mirtazapine, ASIO Journal of Drug Delivery (ASIO-JDD), 2025, 7(1): 01-09.

ARTICLE TYPE: REVIEW

DOI Link:: http://doi-ds.org/doilink/10.2016-21915953/ ; DOI Link :: https://doi-ds.org/doilink/06.2025-42926254/ASIO-JDD/V7/I1/LS

ABSTRACT

Depressed mood, loss of interest or pleasure, guilt or low self-esteem, interrupted sleep or food, low energy, and difficulty concentrating are all symptoms of depression, a common mental illness. The antidepressant medication mirtazapine has a remarkable pharmacological profile. Additionally, its safety and tolerability profile is outstanding. In this study, a fast-dissolving tablet of mirtazapine (MTZ) was developed and evaluated utilizing co-processed excipients that contained mannitol and sodium starch glycolate. It is predicted that using a fast-dissolving dosage form will boost bioavailability and increase permeability across the blood-brain barrier due to its lipophilic nature. The formulation MFSC8 containing of sodium starch glycolate and croscarmellose sodium was found to have a higher percentage of dissolved in 5 minutes and to release the maximum amount within 1 to 2 hours, according to the physical characteristics of Mirtazepine fast dissolving tablets, in-vitro disintegration time, and in-vitro dissolution studies. As a result, MFSC8 is regarded as the best version of mirtazepine. We may conclude that the formulation of the tablet that contains mirtazepine can improve the drug's therapeutic efficacy.

Keywords:  Mirtazapine, sodium starch glycolate and croscarmellose sodium, Microcrystalline Cellulose, fast-dissolving tablet, Bioavailability.

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