ARTICLE DESCRIPTION:
Yong-Chol Hong, Song-Kwon Pak, IL-Kyong Ko, Hyong-Gun Ri, Changes in inflammatory parameters and factors affecting the follicular membrane during intrauterine fetal growth restriction: Basic research, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2025, 8(1): 07-10.
Yong-Chol Hong, Song-Kwon Pak, IL-Kyong Ko, Hyong-Gun Ri
Department of Obstetrics and Gynecology, Pyongyang University of Medical Sciences, Ryonhwa Dong, Central District, Pyongyang, Democratic People’s Republic of Korea.
We observed changes in inflammatory parameters, i.e., neutrophils, macrophages, and lymphocytes, in the oocyte during IUGR and analyzed the factors that influence it.
Background and Aim: Intrauterine growth Restriction (IUGR) is a predictor of weight loss below 10% or −1.5SD of the mean fetal growth curve for gestational age, with inhibition of fetal growth and maturation in utero. Intrauterine growth retardation (IUGR) is an important health problem worldwide. In developed countries, more than 9% of all pregnancies are complicated by IUGR, which is equivalent to about 30 million neonates worldwide. IUGR is defined as the fetus not reaching its genetic developmental potential and is secondary to preterm birth as the major cause of perinatal death. It is commonly caused by a condition known as placental hypofunction, placental insufficiency, which causes chronic hypoxemia and reduces the supply of nutrients to the fetus, and consequently affects organogenesis and fetal body development. In this regard, many countries are working on this topic.
Object: The experiments were conducted in 200-250 g rats.
Methodology: LPS was administered intraperitoneally in rats to provide an IUGR model. On day 20 after conception, the placenta was removed and the follicle was harvested and microscopically examined for neutrophils, macrophages, and lymphocyte infiltration in the follicle as an indicator of inflammation. Then, the experimental group was divided into three groups, group 1 was under ischemic conditions, group 2 was under hypoxic conditions, and group 3 was subjected to indirect smoking conditions to model and observe inflammatory parameters.
Results: In the intrauterine fetal growth retardation model, the number of neutrophils and gestational phagocytes infiltrated into the oocyte membrane was significantly higher than in the normal group, but there was no significant difference in lymphocyte count. Ischemia, hypoxia, and passive smoking during intrauterine fetal growth retardation showed significant changes in inflammatory parameters, neutrophils, macrophages, and lymphocyte infiltration in the membrane.
Conclusion: There was a significant inflammatory change in the membranes of rats with delayed intrauterine fetal growth when exposed to ischemia, passive smoking, and hypoxia.
Keywords: Intrauterine fetal growth retardation; Fallopian membranes; Inflammatory parameters; Ischemia; Indirect smoking; Hypoxia.
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