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JOURNALS || ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR) [ISSN: 2455-281X]
PREFORMULATION STUDIES OF ACYCLOVIR WITH SPECIAL REFERENCE TO DEVELOPMENT OF ANALYTICAL METHODS, CRYSTAL PROPERTIES OF DRUG AND DRUG- EXCIPIENTS INTERACTION STUDIES

Author Names : Ashish Kumar Gupta
Page No. : 01-08  volume 2 Issue 2
Article Overview

ARTICLE DESCRIPTION: 

Ashish Kumar Gupta, Minakshi Verma, Preformulation Studies of Acyclovir with Special Reference to Development of Analytical Methods, Crystal Properties of Drug and Drug- Excipients Interaction Studies, ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR), 2(2), 2016: 01-08.

ARTICLE TYPE: Research

dids/doi No.: 12.2015-77737978

dids link:  http://dids.info/didslink/06.2016-38182138/


ABSTRACT:

The main objective of this work was to develop the Preformulation studies of acyclovir. Preformulation study was mainly performed to develop simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of Acyclovir, an antiHIV drug, in bulk and pharmaceutical dosage form. Various parameters like melting point, pKa, Ko/w, flow properties of the powder drug, crystal morphology, drug excipients compatibility studies and particle size distribution were carried out. The solvent used was 0.1N HCl and the λmax or the absorption maxima of the drug was found to be 255nm. The regression co-efficient obtained from the standard plots were nearing about 1.0 and which proved the linearity of the analytical methods. Calibration curves followed the linear regression. All the models followed Beer-Lambert’s law and therefore can be analyzed by UV spectrophotometer. This method can be used for the determination of Acyclovir in quality control of formulation without interference of the excipients.

Keywords: Acyclovir, pKa, Ko/w, flow properties of the powder drug, crystal morphology, drug excipients compatibility studies and particle size distribution, UV-Vis Spectro photometry

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