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JOURNALS || ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR) [ISSN: 2455-281X]

Author Names : Sakshi Minocha
Page No. : 07-19  volume 3 issue 1
Article Overview


The ubiquity of diabetes is rapidly rising all over the globe at an alarming rate. Over the last three decades, the status of diabetes has been changed, earlier it was considered as a mild disorder of the elderly people. Now it becomes a major cause affecting the youth and middle aged people. Diabetes insipidus (DI) is a complex disease. It is inability of the body to conserve water. Polydipsia and polyuria are the major manifestations of DI. The proper management of DI is the replenishment of water loss. The best management for primary polydipsia is fluid restriction while fluid intake is used for adipsic diabetes insipidus.  Diabetes mellitus is an endocrinological or metabolic disorder with an increasing global prevalence and incidence. High blood glucose levels are symptom of diabetes mellitus. It is associated with metabolic complications that can subsequently lead to premature death.  The most disturbing trend is the shift in age of onset of diabetes to a younger age in the recent years. It is necessary to identify the diabetic patients at the earliest and provide appropriate lifestyle changes in preventing the onset of diabetes.

Keywords: polydipsia, insulin, glucose, Diabetes insipidus, polyuria.

  1. Chan JCM, Kemp S, Roth KS, Wilson TA. Pediatric diabetes Insipidus. Medescape. 2013.
  2. Cagno JM. Diabetes insipidus. Crit Care Nurse. 1989; 9:86-93.
  3. Treschan TA Peters J. The vasopressin system: physiology and clinical strategies. Anesthesiology. 2006;105:599-612.
  4. Gargan. Pituitary Gland and Hypothalamus. Biology 2402. Studyblue. Available at: and hyphothalamus/deck/1041967. Accessed 5th Nov 2015.
  5. Saborio P, Tipton GA, Chan JCM. Diabetes Insipidus. Pediatric in Review. 2000;21:122-129.
  6. Ghiradello S, Garre ML, Rossi A, Maghnie M. The diagnosis of children with central diabetes insipidus. J Pediatr Endocrinol Metab. 2007; 20:359-75.
  7.  Singer I, Oster JR, Fishman LM. The management of diabetes insipidus in adults. Arch Intern Med. 1997; 157:1293-1301.
  8.  Adam P. Evaluation and management of diabetes insipidus. Am Fam Physician. 1997;55:2146-53.
  9. Olson BR, Gumowski J, Rubino D, Oldfield EH. Pathophysiology of hyponatremia after transsphenoidal pituitary surgery. J Neurosurg. 1997; 87:499-507.
  10. Salata RA, Verbalis JG, Robinson AG. Cold water stimulation of oropharyngeal receptors in man inhibits release of vasopressin. J Clin Endocrinol Metab. 1987; 65:561-567.
  11.  Williams RM, Henry C. Nephrogenic diabetes insipidus transmitted by females and appearing during infancy in males. Ann Intern Med. 1947; 27:84-95.
  12.  Leonilde B, Giuseppe P, David Q-H W. A novel therapeutic effect of statins on nephrogenic diabetes insipidus. J. Cell. Mol. Med. 2015; 19(2):265-82.
  13.  Timmer RT, Sands JM. Lithium intoxication. J Am Soc Nephrol. 1999; 10:666-74.
  14.  Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med. 1994; 97:383-9.
  15.  Kovacs L, Lichardus B. Vasopressin, Disturbed Secretion and Its Effects. Prague: Kluwer Academic Publishers. 1989.
  16.  Zhang Z, Kindrat AN, Sharif-Naeini R, Bourque CW. Actin filaments mediate mechanical gating during osmosensory transduction in rat supraoptic nucleus neurons. J Neurosci. 2007; 27:4008-13.
  17.  Frøkiaer J, Marples D, Knepper MA, Nielsen S. Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol. 1996; 270:657-68.
  18.  Sands JM, Flores FX, Kato A, Baum MA, Brown EM, Ward DT. Vasopressinelicited water and urea permeabilities are altered in IMCD in hyper-calcemic rats. Am J Physiol. 1998; 274:978-85.
  19.   Marples D, Frøkiaer J, Dørup J, Knepper MA, Nielsen S. Hypokalemia induced down regulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest. 1996;97:1960-8.
  20.  Aleksandrov N, Audibert F, Bedard MJ, Mahone M, Goffinet F, et al. Gestational diabetes insipidus: a review of an underdiagnosed condition. J Obstet Gynaecol Can. 2010; 32:225-231.
  21.   Peters M, Jeck N, Reinalter S, Leonhardt A, Tönshoff B, et al. Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies. Am J Med. 2002; 112:183-190.
  22.  Verbalis JG, Berl T. Disorders of water balance. Brenner BM. The Kidney. 8. WB Saunders; 2007. 8.
  23.   Sinha A, Ball S, Jenkins A, Hale J, Cheetham T. Objective assessment of thirst recovery in patients with adipsic diabetes insipidus. Pituitary. 2011; 14(4):307-11.
  24.   Mavrakis AN, Tritos NA. Diabetes insipidus with deficient thirst: report of a patient and review of the literature. Am J Kidney Dis. 2008; 51(5):851-9.
  25.  Robertson GL. Differential diagnosis of polyuria. Annu Rev Med. 1998;39:425-42.
  26.  Goldman MB, Robertson GL, Luchins DJ, Hedeker D. The infuence of polydipsia on water excretion in hyponatremic, polydipsic, schizophrenic patients. J Clin Endocrinol Metab. 1996;81:1465-70.
  27.  Goldman MB, Luchins DJ, Robertson GL. Mechanisms of altered water metabolism in psychotic patients with polydipsia and hyponatremia. N Engl J Med. 1998;318:397-403.
  28.  Vieweg WV, Carey RM, Godleski LS, Tisdelle DA, Pruzinsky T. The syndrome of psychosis, intermittent hyponatremia, and polydipsia: Evidence for diurnal volume expansion. Psychol Med. 1990;8:135-144.
  29.  Valtin H. Drink at least eight glasses of water a day. Really? Is there scientific evidence for “8×8”? Am J Physiol Regul Integr Comp Physiol. 2002;283:993-1004.
  30.  Maccubbin DA, Van Buren JM (1963) A quantitative evaluation of hypothalamic degeneration and its relation to diabetes insipidus following interruption of the human hypophyseal stalk. Brain 86: 443-464.
  31.  Atmaca H, Tanriverdi F, Gokce C, Unluhizarci K, Kelestimur F (2007) Posterior pituitary function in Sheehan’s syndrome. Eur J Endocrinol 156: 563-567.
  32.   Zerbe RL, Robertson GL (1981) A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria. N Engl J Med 305: 1539-1546.
  33.   Pivonello R, Colao A, Di Somma C, Facciolli G, Klain M, et al. (1998) Impairment of bone status in patients with central diabetes insipidus. J Clin Endocrinol Metab 83: 2275-2280.
  34.  Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, et al. (2005) Causes of reversible nephrogenic diabetes insipidus: a systematic review. Am J Kidney Dis 45: 626-637.
  35.   Bendz H, Aurell M (1999) Drug-induced diabetes insipidus: incidence, prevention and management. Drug Saf 21: 449-456.
  36.  Shapiro SR, Werner S, Adelman RD, Palmer JM (1978) Diabetes insipidus and hydronephrosis. J Urol 119: 715-719.
  37.  Robben JH, Knoers NV, Deen PM (2006) Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus. Am J Physiol Renal Physiol 291: F257-270.
  38.  Kumar PJ, Clark M. Textbook of Clinical Medicine. Pub: Saunders (London), pp 1099-1121, 2002.
  39.  Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183-1197.
  40.  Beverley B, Eschwège E. The diagnosis and classification of diabetes and impaired glucose tolerance. In: Textbook of Diabetes 1 Ed: John C Pickup and Gareth Williams Third edition; Chapter 2, pp 2.1-2.11, 2003.
  41.   Lindberg G, Lindblad U, Melander A. Sulfonylureas for treating type 2 diabetes mellitus. Cochrane Database Systemic Reviews volume 3, 2004.
  42.  Bearse MA Jr, Han T, Schneck ME, et al. Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy. Invest Ophthal Vis Sci 2004; 45 : 3259-3265.
  43.  Hove MN, Kristensen JK, Lauritzen T, Bek T. The prevalence of retinopathy in an unselected population of type 2 diabetes patients from Arhus County, Denmark. Acta Ophthalmol Scand 2004; 82: 443-448.
  44.  Seki M, Tanaka T, Nawa H, et al. Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factors for dopaminergic amacrine cells. Diabetes 2004; 53: 2412-2419.
  45.  Svensson M, Eriksson JW, Dahlquist G. Early glycemic control, age at onset, and development of microvascular complications in childhood-onset type 1 diabetes: a population-based study in northern Sweden. Diabetes Care 2004; 27: 955-962.
  46.  Saely CH, Aczel S, Marte T, et al. Cardiovascular complications in type 2 diabetes mellitus depend on the coronary angiographic state rather than on the diabetes state. Diabetologia 2004; 47: 145-146.
  47.  Betschart J, Thom S. In control – A guide for teens with diabetes. Minneapolis, MN: Chronimed Publishing, 1995.
  48.  Craig ME, Hattersley A, Donaghue KC (2009) Definition, epidemiology and classification of diabetes in children and adolescents. Pediatr Diabetes 10 Suppl 12: 3-12.
  49.  Cryer PE (2006) Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes. J Clin Invest 116: 1470-1473.
  50.  Al Homsi MF, Lukic ML (1992) An Update on the pathogenesis of Diabetes Mellitus, Department of Pathology and Medical Microbiology (Immunology Unit) Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
  51.  American Diabetes Association (2011) Standards of Medical Care in Diabetes-2011. Diabetes Care 34: S11-61.
  52.  Gillett MJ (2009) International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes: Diabetes Care 2009; 32(7): 1327-1334. Clin Biochem Rev 30: 197-200.
  53.  Giuliano F, Bannwarth S, Monnot S, Cano A, Chabrol B, Vialettes B, Delobel B, Paquis- Flucklinger V: Wolfram syndrome in French population: characterization of novel mutations and polymorphisms in the WFS1 gene.
  54.  H. Y. Yap, C. K. Tashima, G. R. Blumenschein, and N. Eckles, “Diabetes insipidus and breast cancer,” Archives of Internal Medicine, vol. 139, no. 9, pp. 1009–1011, 1979.
  55.  A. M.Moses, “Clinical and laboratory observations in the adult with diabetes insipidus and related syndromeseds,” in Diabetes Insipidus in Man. Frontiers of Hormone Research, P. Czernichow and A. G. Robinson, Eds., vol. 13, p. 156, S Karger, Basel, Switzerland, 1985.