An International Publications House

Albert Science International Organization

Connecting People With Pioneering Thought

Albert Science International Organization (ASIO) is international , peer-reviewed , open access , cum print version & online journals.
JOURNALS || ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR) [ISSN: 2455-7080]
AN OVERVIEW OF ANTIOXIDANT: CLASSIFICATIONS, THERAPEUTIC EFFECT & ITS APPLICATIONS

Author Names : Tamal Maity
Page No. : 27-34  volume 1 issue 1
Article Overview

ARTICLE DESCRIPTION: 

Tamal Maity, Sounik Banerjee, Amlan Bishal, Rupajit Bhattacharjee, Satya Prasanna Das, Moumita Maji, An Overview of Antioxidant: Classifications, Therapeutic Effect & Its Applications, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2016, 1(1): 27-34.

ARTICLE TYPE: REVIEW

dids no.: 03.2016-35559215,  

dids Link:   http://dids.info/didslink/03.2016-67718634/

 


ABSTRACT:

Antioxidants are substances that are able to neutralize reactive molecules and reduce oxidative damage like Vitamin C, Vitamin E, beta-carotene, Vitamin A, selenium, iron, zinc, copper and manganese. Oxidation reactions are very important for life, they can also be detrimental; hence, plants & animals maintain complex systems of multiple types of antioxidants, such as Glutathione, Vitamin C & Vitamin E and enzymes like Super oxide dismutase, Catalase and various Peroxidases. Minor levels of antioxidants, or inhibition of antioxidant enzymes, causes oxidative stress and also may damage or kill the cells. L-ascorbate, Beta-carbonate, Alpha-tocopherol may stop skin diseases linked to sun exposure like sunburn, photo immuno-supression photo ageing, photo-carcinogenesis. Vitamin C, Methionine and Selenium act as safe & proficient medical substitute to surgery for painful chronic pancreatitis. A recently developed technique for measuring free radical production shows promise in producing more valid results. The technique uses monoclonal antibodies and may confirm to be the most accurate measurement of free-radicals. Antioxidants can repair endothelial function and decrease blood pressure in severe models of hypertension. Probucol, a lipid-lowering agent, has also antioxidant activity. The main goal of this review is to search various important of antioxidants and their health benefits in the field of health care system.

Keywords: Oxidation, Anti oxidants, Classifications, Applications

Reference
  1. Krum H, Carson P, Farsang C. Effect of valsartan added to background ACE inhibitor therapy in patients with heart failure: results from Val-HeFT, Eur J Heart Fail, 2004, 6(7):937-45.
  2. Solomon SD, Skali H, Anavekar NS. Changes in ventricular size and function in patients treated with valsartan, captopril, or both after myocardial infarction, Circulation, 2005, 111(25):3411-9.
  3. Yang Y, Ohta K, Shimizu M. Treatment with low-dose angiotensin-converting enzyme inhibitor (ACEI) plus angiotensin II receptor blocker (ARB) in pediatric patients with IgA nephropathy, Clin Nephrol, 2005, 64(1):35-40.
  4.  Nag KKF and Vane JR. Conversion of angiotensin I to angiotensin II, Nature, 1967, 216, 762-766
  5. Nag KKF and Vane JR. Fate of angiotensin I in the circulation”. Nature 1968, 218, 144-150.
  6. Solomon, Scott D, Anavekar N. A Brief Overview of Inhibition of the Renin-Angiotensin System: Emphasis on Blockade of the Angiotensin II Type-1 Receptor, Medscape Cardiology, 2005, 9 (2), 12-18.
  7. Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin-angiotensin systems, Physiol. Rev., 2006, 86 (3): 747–803.
  8. Patil J, Heiniger E, Schaffner T, Mühlemann O, Imboden H. Angiotensinergic neurons in sympathetic coeliac ganglia innervating rat and human mesenteric resistance blood vessels,  Regul. Pept. 2008, 147 (1-3): 82–7.
  9. Gradman A, Schmieder R, Lins R, Nussberger J, Chiang Y, Bedigian M. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients, Circulation, 2005, 111 (8):1012–18.
  10. Richter WF, Whitby BR, Chou RC. Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals, Xenobiotica, 1996: 26 (3): 243–54.
  11. Tissot AC. Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomized, placebo-controlled phase II a study, The Lance, 2008, 371, pp. 821-827. 
  12. Satoskar Rs. Bhandarkar SD. Aaniapure SS. In: Pharmacology and Pharmacotherapeutics, 17th ed. Mumbai: Popular Prakashan, 2003, pp-175-177.
  13. Rang HP, Dale MM, Ritter JM, Moore PK. In: Pharmacology.4th Ed. New Delhi. Churchill Livingstone, 2003, P-273-75.
  14. Benette PN. In: Clinical Pharmacology. Editor Brown MJ. 9th Ed. New Delhi. Churchill Livingstone, 2004, p-17.