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JOURNALS || ASIO Journal of Chemistry, Physics, Mathematics & Applied Sciences (ASIO-JCPMAS) [ISSN: 2455-7064 ]
SYNTHESIS OF 1-ARYL-[MERCAPTO-(P-CHLORO BENZOYL)-METHYL]-4 [PHNYL/P-CHLORO PHENYL]-IMIDAZOLES AND THEIR ACETYL CHOLINE ESTERASE INHIBITORY ACTIVITY

Author Names : Dr. Uma Singh
Page No. : 01-03  volume 1 issue 1
Article Overview

ARTICLE DESCRIPTION: 

Uma Singh, Padam Kant, J Singh Gaur, Synthesis of 1-Aryl-[Mercapto-(P-Chloro Benzoyl)-Methyl]-4 [Phnyl/P-Chloro Phenyl]-Imidazoles and their Acetyl Choline Esterase Inhibitory Activity, ASIO Journal of Chemistry, Physics, Mathematics & Applied Sciences (ASIO-JCPMAS), 2016, 1(1): 01-03.

ARTICLE TYPE: RESEARCH

dids no.: 03.2016-26169319,

dids Link: http://dids.info/didslink/03.2016-82544922/


ABSTRACT:

Twelve 1-aryl -2-[mercapto (p –chlorobenzoyl)-methyl1]-4-[phenyl/p-chlorophenyl]-imdidazoles (iii a-1) were synthesized by the condensation of various 1-aryl -2-mercapto-4[phenyl/p-chlorophenyl]-imidazole (Ia-1) with 4-chlorophenyl bromide (II). All the synthesized compounds were evaluated for their inhibitory properties towards choline esterase activity. Bactericidal activity of these compounds was also studied in vitro method. None of the compounds possessed significant choline esterase inhibitory activity. The compound (IIIa, c, h) were found to be moderately good antibacterial agents against bacillus pumilus, Baccilus cereus.

Keywords: Imdidazoles, chlorophenyl bromide, antibacterial agents

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