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JOURNALS || ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR) [ISSN: 2455-281X]
MICRO-EMULSION: AN OVERVIEW

Author Names : Preeti Kamaria
Page No. : 05-16  volume 1 issue 1
Article Overview

ARTICLE DESCRIPTION: 

Preeti Kamaria, Anamika Saxena, Ayushi patwa, Ashok Dashora. Micro-Emulsion: An Overview, ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR), 2015, 1(1): 05-16.

ARTICLE TYPE: REVIEW

dids/doi No.: 12.2015-77737978

dids link: http://dids.info/didslink/12.2015-77128968/ 


ABSTRACT:

Micro-emulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water and surfactant, frequently in combination with a co-surfactant with a droplet size usually in the range of 20-200 nm. They can be classified as oil-in-water (o/w), water-in-oil (w/o) or bi-continuous systems depending on their structure and are characterized by ultra low interfacial tension between oil and water phases. These adaptable delivery systems provide protection against oxidation, enzymatic hydrolysis and improve the solubilization of lipophilic drugs and hence enhance their bioavailability. Micro-emulsion formulated with suitable excipients may also prove to be suitable vehicles for delivery of labile (peptide) and poorly soluble drugs. Micro-emulsions have higher solubilising capacities than simple micellar solution and their thermodynamic stability  offers advantages over unstable dispersions, such as emulsions, suspensions because they can be manufactured with little energy input and have a long shelf life, the enormous interfacial areas associated with  micro-emulsions would influence the transport properties of drug, an important factor in targeted and sustained drug delivery through ophthalmic, dental, pulmonary, vaginal and topical routes.

KEYWORDS: Micro-emulsion, Thermodynamic stability, co-surfactant, phase behavior study, Targeted delivery

Reference
  1. Hoar TP and Schulman JH. Transparent water in oil dispersions: the oleopathic hydromicelle, Nature, 1943, 152: 102 – 103.

  2. Attwood D, Kreuter J. Colloidal Drug Delivery Systems,New York, Marcel Dekker, 1994,  31–71.

  3. Derle DV, Sagar BSH, Micro-emulsion as a vehicle for transdermal permeation of nimesulide, Indian Journal of Pharmaceutical Sciences, 2006, 68(5): 622-625.

  4.  Singh Ajit, Prajapati SK, Kumar Shailendra, Singh Ankush. Micro-emulsions for Topical Drug Carrier: A Review, IJMPR, 2013, 1(4): 376-380.

  5. Talegaonkar Sushama, Azeem Adnan, J Ahmad Farhan, Khar Roop K, Pathan Shadab A and Khan Zeenat I. Micro-emulsions: A Novel Approach to Enhanced Drug Delivery; Recent Patents on Drug Delivery & Formulation, 2006, 2: 238-257.

  6. Khanna S, Katare OP, Nasa A, Garg A. Micro-emulsions: Developmental aspects, Research Journal of Pharmaceutical Biological and Chemical Sciences.

  7. Katiyar Bipin Sarvesh, Katiyar Sameer Sarvesh, Mishra Preeti Satishchandra, Sailaja Duvvuri Lakshmi. Micro-emulsions: A Novel Drug Carrier System, Int. J. Pharm. Sci. Rev. Res, 2013. 20(2), 24: 138-148.

  8. Sarkhejiya Naimish A , Nakum Mayur A, Patel Vipul P, Atara Samir A, Desai Thusarbindu R. Emerging Trend Of Micro-emulsion In Formulation And Research, International Bulletin Of  Drug Research, 2013, 1(1):54-83.

  9. Kumar P and Mittal KL. In Handbook of Micro-emulsion Science and Technology, 1st Edn, CRC Press,New York, 1999, 1.

  10. Patel MR. Micro-emulsions: As Novel Drug Delivery Vehicle, www.pharmainfo.net / reviews / micro-emulsion as novel drug delivery vehicle, 2007.

  11. Lam AC, Schechter RS. The theory of diffusion in micro-emulsions, Journal of Colloid Interface Science, 1997, 120:56-63.

  12. Winsor P. A. Trans. Faraday Soc.; 1948, 44:376.

  13. Shinoda K, Saito HJ. Colloid Interface Sci.; 1969, 34: 238.

  14. Kyatanwar AU, Jadhav KR and Kadam VJ. Self Micro-Emulsifying Drug Delivery System (SMEDDS): Review,Journal of Pharmacy Research, 2010, 3: 75-83.

  15. Pouton CW and Porter CJ. Formulation of Lipid-based Delivery Systems for Oral Administration: Materials, Methods and Strategies, Ad. Drug Delivery Rev., 2008, 60: 625–637.

  16. Kibbe AH. Handbook of Pharmaceutical Excipients,3rd Edn, London Pharmaceutical Press: 2000, 407.

  17. Shafiq-un-Nabi. Formulation development and optimization using nanoemulsion technique: a technical note, AAPS Pharm Sci Tech, 2007, 8(2) :1-6.

  18. Croft, WJ. Under the microscope: a brief history of microscopy. Series in popular science, Hackensack, NJ: World Scientific, 2006, 13:138.

  19. Lawrence MJ, Rees GD. Micro-emulsion based media as novel drug delivery systems, Adv Drug Deliv Rev, 2000, 45(1):89-121.

  20. Shah RR, Magdum CS, Wadkar KA, Naikwade NS. Fluconazole Topical Micro-emulsion: Preparation and Evaluation, Research J. Pharm. and Tech, 2009, 2(2).

  21. Zheng HL, Xiao LZ, Peng YY. Effect of Addition of Cosurfactant on the Phase Behaviour of Oil-in-water Aminosilicone Oil Microemuls, Chinese Chemical Letters, 2004, 15(9): 1101-1104.

  22. Jha SK, Dey S, Karki R. Micro-emulsions-Potential Carrier for Improved Drug Delivery, Internationale Pharmaceutica Sciencia,2011, 1(2).

  23. M Jayne Lawrencea, Gareth D. Reesb.  Micro-emulsion-based media as novel drugdelivery systems, Advanced Drug Delivery Reviews, 2000, 45: 89–121.

  24. Pathan M, Zikriya A, Quazi A. Micro-emulsion: As Excellent Drug Delivery System, International Journal for Pharmaceutical Research Scholars (IJPRS): 2012, 1(3).

  25. Ghosh PK, Murthy RS. Micro-emulsions: A potential drug deliverysystem, Current Drug Delivery, 2006, 3(2): 167-180.

  26. Katiyar Bipin Sarvesh, Katiyar Sameer Sarvesh, Mishra Preeti Satishchandra, Sailaja Duvvuri Lakshmi. Micro-emulsions: A Novel Drug Carrier System, Int. J. Pharm. Sci. Rev. Res, 2013, 20(2), 24: 138-148.

  27. Patel MR. Micro-emulsions: As Novel Drug Delivery Vehicle, www. pharmainfo. Net / reviews / micro-emulsion as novel drug delivery vehicle, 2007.

  28. Sinko PJ, and Singh Y. Martin’s Physical Pharmacy and Pharmaceutical Sciences, 5th Edn, Lippincott Williams & Wilkins publications, Philadelphia : 2005, 410.

  29. Acosta E, Kurlat DH, Bisceglia M, Ginzberg B, Baikauskas L and Romano SD. Induced Electric Birefringence and Viscosity Studies in Micro-emulsions, Colloids Surfaces A: Physicochem. Eng. Aspects, 1996, 106:11–21.

  30. Schurtenberger P, Peng Q, Leser ME and Luisi PL. Structure and Phase Behaviour of Lecithin-based Micro-emulsions: A Study of Chain Length Dependence, J. Colloid Interface Sci., 1993, 156: 43–51.

  31. Shinoda K, Araki M, Sadaghiani A, Khan A and Lindman B. Lecithin-based Micro-emulsions: Phase Behaviour and Microstructure, J. Phys. Chem., 1991, 95: 989–993.

  32. Vyas SP, and Khar RK. In Submicron Emulsions in Targeted and Controlled Drug Delivery, Novel Carrier Systems, 1st Edn, CBS Publishers and Distributors, New Delhi: 2002, 282.

  33. Mehta SK, Kavaljit XX and Bala K. Phase Behaviour, Structural Effects, Volumetric and Transport Properties in Non aqueous Micro-emulsions, Phys. Rev., 1999, 59: 4317–4325.

  34. Hasse A and Keipert S. Development and Characterisation of Micro-emulsions for Ocular Application, European Journal of Pharmaceutics and Biopharmaceutics, 1999, 43: 179–183.

  35. Kumar P, and Mittal KL. In Handbook of Micro-emulsion Science and Technology, 1st Edn, CRC Press, New York: 1999, 411.

  36. Sarkhejiya Naimish A, Nakum Mayur A, Patel Vipul P, Atara Samir A, Desai Thusarbindu R.  Emerging Trend Of Micro-emulsion In Formulation And Research, International Bulletin Of Drug Research., 1(1): 54-83

  37. Aungst BJ. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism, Journal of Pharmaceutical Sciences, 1993, 82: 979-986.

  38. Raimar LE, Gordon LA. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards, European Journal of Pharmaceutics and Biopharmaceutics, 2000, 50: 3-12

  39. Sariciaux MJ, Alan L, Sado PA. Using micro-emulsion for drug delivery of therapeutic peptides, International Journal of Pharmaceutics, 1995, 12: 127-136.

  40. Swenson EC, Curatolo WJ. Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanism and potential toxicity, Advanced Drug Delivery Reviews, 1992, 8:39-42.

  41. Shaw JM. Lipoproteins as carriers of pharmacological agents, Marcel Dekker, Journal Of Pharmaceutical Sciences, 1991, 97-139.

  42. Naicker SA, Yatscoff RW, Foster RT. 2006: US20067060672.

  43. Jumma M, Muller BW. The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions, International Journal of Pharmaceutics, 1998, 163: 81-89.

  44. Yiv SH, Tustian AK. 2001: US20016245349.

  45. Vandamme TF. Micro-emulsions as ocular drug delivery systems: recent developments and future challenges, Progress in Retinal and Eye Research, 2002, 21:15-24.

  46. Lianly IL, Nandi I, Kim KH. Development of an ethyl laurate based micro-emulsion for rapid onset of intranasal delivery of diazepam, International Journal of Pharmaceutics, 2002, 237: 77-85.

  47. Brodin A, Fynes R, Heijl R, Nyqvist-Mayer A, Scherlund M. 2000: US20006031007.

  48. Monahan SD, Wolff JA, Slattum PM, Hagstrom JE, Budker VG. 2002: US20026429200.

  49. Lieberman HA, Rieger MM, Banker GS. Pharmaceutical Dosage Forms: Disperse System, 2nd ed, Marcel Dekker Inc, New York, 1996, 1:211–281,315–370.

  50. Puranajoti PR, Patil T, Sheth PD, Bommareddy GP, Egbaria DK. Design and Development of Topical Micro-emulsion for Poorly Water-Soluble Antifungal Agents, The Journal of Applied Research, 2002, 2(1):100-107.

  51. Date AA, Naik B, Nagarsenker MS. Novel Drug Delivery Systems: Potential in Improving Topical Delivery of Antiacne Agents, Skin Pharmacology and Physiology, 2006, 19: 2-16.

  52. Peira E, Carlotti ME, Cavalli R, Trotta M. Azelaic acid sodium salt in the formulation of micro-emulsions for topical applications, Journal of drug delivery science and technology, 2006, 16(5): 375-379.

  53. Martini MC, Bobin MF, Flandin H, Caillaud F, Cotte J. Role of micro-emulsions in the percutaneous absorption of alpha tocopherol, Journal de Pharmacie de Belgique, 1984, 39(6): 348-54.

  54. Branka R, Alenka Z, Francoise F, Mirjana G. Temperature-Sensitive Micro-emulsion Gel: An Effective Topical Delivery System for Simultaneous Delivery of Vitamins C and E, AAPS PharmSci Tech, 2009, 10(1):54- 6.

  55. Chan J, Gamal MM, Maghraby El, Jennifer PC, Raid GA. Phase transition water-in-oil micro-emulsions as ocular drug delivery systems: In vitro and in vivo evaluation, International Journal of Pharmaceutics, 2007, 328(1): 65-71.

  56. D'Cruz O. Gel-micro-emulsions as vaginal spermicides and intravaginal drug delivery vehicles. Contraception, AAPS Pharm Sci Tech, 2001, 64(2):113.

  57. Azeem A, Rizwan M, Ahmad FJ. Emerging role of micro-emulsionsin cosmetics, Recent Patents on Drug Delivery and Formulation, 2008, 2(3): 275-89.

  58. Paul BK, Moulik SP. Uses and Applications of Micro-emulsions, Current Science, 2001, 80 (8): 990 – 1001.