Gouranga Nandi, Sailee Chowdhury, Sudipta Chakroborty. An Overview of Natural Polysaccharides and their Chemical Modifications: Application in Drug Delivery, ASIO Journal of Drug Delivery (ASIO-JDD), 2015, 1(1): 37-43.
ARTICLE TYPE: REVIEW
dids/doi No.: 12.2015-38368922
Dids Link : http://dids.info/didslink/12.2015-81221248/
In recent years, worldwide extensive efforts are being paid in exploration of pharmaceutical excipients from natural origin. Various natural polysaccharides have been substantially reported as potential drug delivery carriers. These natural polymers are preferred over synthetic polymers because of their biocompatibility, low cost, free availability and biodegradability. The native forms pose certain drawbacks like variable chemical composition, variable swelling kinetic, microbial load, microbial growth and change in viscosity upon aging. These negative aspects make them less acceptable compared to commercial synthetic products. Modification of their chemical structure makes them intelligent biomaterials in controlled release applications. This article is aimed at discussing chemical modifications of natural polysaccharides like carboxymethylation, grafting, blending, cross-linking and so on that are useful of making them suitable as potential drug carrier. The pharmaceutical applications of various natural polysaccharides and their modified forms for the development of various drug delivery systems has also been described.
Key words: Natural polysaccharides, chemical modification, grafting, drug delivery.
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