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JOURNALS || ASIO Journal of Drug Delivery (ASIO-JDD) [ISSN: 2455-2828]
DEVELOPMENT OF AN OPTIMIZED, SUSTAINED RELEASE OFLOXACIN TABLET FOR VAGINAL DELIVERY

Author Names : Manas Jyoti Kapil
Page No. : 01-12  volume 3 issue 1
Article Overview

ARTICLE DESCRIPTION: 

Manas Jyoti Kapil*, Dr. Parthajyoti Gogoi, Dipankar Das, Neelakshi Sharma & Bornali Hazarika, Development of an Optimized, Sustained Release Ofloxacin Tablet for Vaginal Delivery, ASIO Journal of Drug Delivery, 2018, 3(1): 01-12.

ARTICLE TYPE: RESEARCH

Dids Link :  http://doi-ds.org/doilink/02.2018-47499584/

 



ABSTRACT:

Objective: The aim of the study was to formulate a sustained release Ofloxacin tablet to reduce dosing frequency and prolonged action on the site of administration.

Method: Central composite design for 2 factors at 3 levels each was employed. This gave an optimized drug release profile in a systematic way. Different quantity of HPMC K 15M and Carbopol were selected as the independent variables. Whereas time to 50% drug release (t50%) and drug release at 12hrs (T12) were selected as dependent variables.

Result: The response surface analysis clearly indicated the effect of both polymers on t50 and T12. The two formulations composition with HPMC concentration of 5.02 % w/w and 7.88 % w/w, the amount of Carbopol was 4.01% w/w and 4.16% w/w respectively, fulfilled maximum requirements of an optimum formulation, desirability 1 and 0.957 respectively.

Conclusion: Study concluded that HPMC K15M and Carbopol can be used as release regulators for formulating Ofloxacin vaginal tablets.                                           

KEYWORDS: Polymers, vaginal drug delivery system, sustain release, central composite design, U.V spectrophotometer.

*Corresponding author: Manas Jyoti Kapil, Regional Drugs Testing Laboratory, Guwahati, Assam, India, e mail ID: Manas.kapil@gmail.com

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