An International Publications House

Albert Science International Organization

Connecting People With Pioneering Thought

Albert Science International Organization (ASIO) is international , peer-reviewed , open access , cum print version & online journals.
JOURNALS || ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR) [ISSN: 2455-281X]

Author Names : Pritam Roy
Page No. : 01-06  volume 3 issue 1
Article Overview


Enteric coatings prevent the release of medication before it reaches the  small intestine. The enteric coated polymers remain unionized at low pH, and therefore remain insoluble. But as the pH increases in the GIT, the acidic functional groups are capable of ionization, and the polymer swells or becomes soluble in the intestinal fluid (above pH 5.5). Proton pump inhibitors reduce the production of acid in the stomach. This leaves little acid in the stomach juice so that if stomach juice backs up into the esophagus, it is less irritating. This allows the esophagus to heal. Proton pump inhibitors also work to help symptoms of GERD. Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase  or more commonly, the gastric proton pump) of the gastric parietal cells. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the gastric lumen, making it an ideal target for inhibiting acid secretion.         

Keywords: enteric coating, gastric parietal cells, gastric lumen.

  1. Lachman L, Lieberman HA, Joseph LK. The Theory and Practice of Industrial Pharmacy. Varghese Publishing House; Mumbai; Third Edition: 297-321.     
  2. Lachman L, Liberman HA, Kanig J. The Theory and Practice of Industrial Pharmacy; Third Edition: 293-345, 346-373.
  3. Aulton M. Pharmaceutics: The Science of Dosage Form Design. International Student Edition: 304-321, 347-668.
  4. Vyas S, Khar R. Controlled Drug Delivery Concepts and Advances; First Edition: 219-256.
  5. Ansel H, Allen L, Jr. Popovichorms and N. Drug Ansel’s Delivery Systems; Pharmaceutics Eighth Edition: 227-259.
  6. Remington J. Remington: The Science and Practice of Pharmacy; 2(19): 1615-1641.
  7. American Pharmaceutical Reviews 2001; 4(3): 28-35.
  8. Kumar Vinay. KV, Sivakumar T and Tamizh mani. T, Colon targeting drug delivery.
  9.  Anil K. Philip and Betty Philip, Colon Targeted Drug Delivery Systems: A Review on  Primary and Novel Approaches, Oman Medical Journal, 25(02), 2010, 70-78
  10. Brahmankar DM and Jaiswal SB. Biopharmaceutics and Pharm Treatise” Vallabh Prakasha 347-352.   
  14. John Twist, Ghebre Sellassie; Development of an enteric coating formulation and process for tablets primarily composed of a highly water-soluble, organic acid, Eur J Pharm Biopharm, 2001 Jan; 51(1):71-6.
  15. Mitesh P. Modi, Abin Abraham; Preparation of enteric coated   timed-release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting, Int J Pharm. 2000 Aug 25;204(1-2):7-15.
  16. Haitham F. Mostafa, Mohamed A. Ibrahim, Gamal M. Mahrous, and Adel Sakr; Assessment of the pharmaceutical quality of marketed enteric coated pantoprazole   sodium sesquihydrate products, Saudi Pharm J. 2011 Apr; 19(2): 123–127.
  17. Murat Turkoglu, Hakan Varol, Mine Celikok; Tableting and stability evaluation of enteric-coated omeprazole pellets.Eur J Pharm Biopharm. 2004 Mar;57(2):279-86.
  18. R.P. Raffin, L.M. Colomé, E.E.S. Schapoval, D.S. Jornada, A.R. Pohlmann , S.S.   Guterres; Gastro-Resistant Microparticles Containing Sodium Pantoprazole: Stability Studies and In Vivo Anti-Ulcer Activity, The Open Drug Delivery Journal 2007, 1: 28-35.
  19. Nykanen P, Veski P, Marvola M; Citric acid as excipient in multiple-unit enteric-coated tablets for targeting drugs on the   colon, Int J Pharm. 2001 Oct 23;229(1-2):155-62.
  20. P. Suresh Kumar, S. Navaneetha Krishnan, S. Pavani, Y. Surendarnath, S. Divya and  Y.Sahithi; Formulation and evaluation of rabeprazole sodium delayed release   tablets, Der Pharmacia Lettre, 2012, 4 (1):287-296.
  21. R.P. Raffin, L.M. Colomé, E.E.S. Schapoval, D.S. Jornada, A.R. Pohlmann, S.S. Guterres; Gastro-Resistant Microparticles Containing Sodium Pantoprazole:  Stability Studies and In Vivo Anti-Ulcer ActivityThe Open Drug Delivery Journal , 2007,1:28-35.
  22. S. Bozdag, S. Çalis and M. Sumnu; Formulation and stability evaluation of  enteric-coated omeprazole formulations, S.T.P. PHARMA SCIENCES 9 (4) 321-327,1999.
  23.  Nasr Mohamed, Hassan, Hazem E; Pharmacokinetics and Bioequivalence      Evaluation of Two Omeprazole Enteric-coated Formulations in Healthy Egyptian  Male Volunteers, Journal of Applied Sciences Research; Sep2009, Vol. 5 Issue 9,  p1190.
  24. Debunne A, Vervaet C, Mangelings D, Remon JP; Compaction of enteric-coated   pellets: influence of formulation and process parameters on tablet properties and in vivo evaluation; Eur J Pharm Sci. 2004 Jul;22(4):305-14.
  25. Anroop B Nair1, Rachna Gupta2, Rachna Kumria, Shery Jacob and Mahesh    Attimarad; Formulation and Evaluation of enteric coated   tablets of proton pump inhibitor;
  26.  A. Mukharya, S.A. Chaudhary, A. Bheda, A. Mulay, N.Mansuri, N. Laddha, A. K. Misra; Stable And Bioequivalent Formulation Development Of Highly Acid Labile Proton Pump Inhibitor: Rabeprazole; International Journal of Pharmaceutical Research.
  27. J Williams, A MacDonald, P H Weller, J Fields, and H Pandov Arch Dis Child; Two enteric coated microspheres in cystic fibrosis; 1990 Jun; 65(6): 594-597.PMCID: PMC1792062
  28. K. L. Senthil Kumar, S. Ashok kumar, R. P. Ezhilmuthu; Formulation and Evaluation  of Didanosine Enteric Coated Sustained Release Tablet ; J Biomed Sci and Res;  Vol 2  (3), 2010, Page:126-131.
  29. Dhruba Sankar Goswami , Prasanta Kumar Choudhury , Sandeep Kumar Goyal, Romy Sharma; Formulation Design and Optimization of an Enteric Coated Sustained Release Mucoadhesive Tablet of Metronidazole; International Journal of PharmTech Research CODEN (USA):
  30. Devraj and D. C. Bhatt ; Studies on enteric coated sustained timed-release tablets of Metronidazole; J. Chem. Pharm. Res., 2010.
  31. Abebe Endale, Tsige Gebre-Mariam and Peter C. Schmidt; Granulation by Roller Compaction and Enteric Coated Tablet Formulation of the Extract of the Seeds  of Glinus Lotoides Loaded on Aeroperl® 300 Pharma; AAPS PharmSciTech. 2008 Mar; 9(1): 31–38.
  32. Rabia Bushra, Muhammad Harris Shoaib, Nousheen Aslam, Zafar Alam Mehmood, Durriya Hashmat; Enteric coating of ibuprofen tablets (200 mg) using an aqueous dispersion system; Brazilian Journal of Pharmaceutical Sciences.